Amazon is sponsoring a Breakthrough Novel Award Contest. Enter your manuscript by November 5, 2007, but do it quickly. Only 5,000 novels will be accepted.
A panel of Amazon editors and reviewers will select the semi-finalists, who each get a Publisher's Weekly Review and a page on Amazon with an excerpt of their novel.
Based on customer feedback, Penguin will look at some semi-finalists for possible publication. The winner gets a publishing contract with Penguin, lots of electronics goodies, and help publicizing his or her book. Those who place 2nd through 10th also get some great prizes, including the opportunity to self-publish. This whole contest is to advertise Amazon's new self-publishing division.
You'll need a blurb of your book to enter. If you have a query letter, you can probably adapt it for your book description. If I can get my manuscript polished in time, I may go for it. I'm not sure, however, if they're looking for genre or literary fiction.